About   Help   FAQ
Ciitatm1.1Dim
Targeted Allele Detail
Summary
Symbol: Ciitatm1.1Dim
Name: class II transactivator; targeted mutation 1.1, Diane Mathis
MGI ID: MGI:3664552
Synonyms: CIITA0
Gene: Ciita  Location: Chr16:10297923-10346282 bp, + strand  Genetic Position: Chr16, 5.65 cM, cytoband B1
Alliance: Ciitatm1.1Dim page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:51885
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsA single loxP site was introduced 5' to exon 2 and a loxP-flanked thymidine kinase-neomycin fusion gene was inserted 3' to exon 3. Cre-mediated deletion of the intervening sequences was accomplished by mating mutant mice to CMV-cre mice, deleting the DNA encoding the major transactivation domain. RT-PCR analysis on spleen and thymus RNA indicated that no detectable transcript is expressed from this allele. (J:51885)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ciita Mutation:  46 strains or lines available
References
Original:  J:51885 Williams GS, et al., Mice lacking the transcription factor CIITA--a second look. Int Immunol. 1998 Dec;10(12):1957-67
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
10/29/2024
MGI 6.24
The Jackson Laboratory