Ciitatm1.1Dim
Targeted Allele Detail
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Symbol: |
Ciitatm1.1Dim |
Name: |
class II transactivator; targeted mutation 1.1, Diane Mathis |
MGI ID: |
MGI:3664552 |
Synonyms: |
CIITA0 |
Gene: |
Ciita Location: Chr16:10297923-10346282 bp, + strand Genetic Position: Chr16, 5.65 cM, cytoband B1
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Alliance: |
Ciitatm1.1Dim page
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Germline Transmission: |
Earliest citation of germline transmission:
J:51885
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Parent Cell Line: |
D3 (ES Cell)
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Strain of Origin: |
129S2/SvPas
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Allele Type: |
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Targeted (Null/knockout) |
Mutation: |
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Intragenic deletion
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Mutation details: A single loxP site was introduced 5' to exon 2 and a loxP-flanked thymidine kinase-neomycin fusion gene was inserted 3' to exon 3. Cre-mediated deletion of the intervening sequences was accomplished by mating mutant mice to CMV-cre mice, deleting the DNA encoding the major transactivation domain. RT-PCR analysis on spleen and thymus RNA indicated that no detectable transcript is expressed from this allele.
(J:51885)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Ciita Mutation: |
46 strains or lines available
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Original: |
J:51885 Williams GS, et al., Mice lacking the transcription factor CIITA--a second look. Int Immunol. 1998 Dec;10(12):1957-67 |
All: |
1 reference(s) |
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