Adam33^tm1.1Chch
Targeted Allele Detail

Summary

• Symbol: Adam33^tm1.1Chch
• Name: a disintegrin and metallopeptidase domain 33; targeted mutation 1.1, Chun Chen
• MGI ID: MGI:3664558
• Synonyms: ADAM33^-
• Gene: Adam33 Location: Chr2:130892739-130905734 bp, - strand Genetic Position: Chr2, 63.26 cM
• Alliance: Adam33^tm1.1Chch page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:112306
• Parent Cell Line: RF8 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The floxed exon 1 and neomycin resistance gene in Adam 33^tm1Chch were removed via cre mediated recombination by mating with Tg(Tek-cre)1Rwng mice. Successful gene disruption was demonstrated by QRT-PCR, however LacZ expression was not detected. (J:112306)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adam33 Mutation: 44 strains or lines available

References

• Original: J:112306 Chen C, et al., ADAM33 is not essential for growth and development and does not modulate allergic asthma in mice. Mol Cell Biol. 2006 Sep;26(18):6950-6
• All: 1 reference(s)