Psip1^{Gt(betageo)1Hgs}
Gene trapped Allele Detail

Summary

• Symbol: Psip1^{Gt(betageo)1Hgs}
• Name: PC4 and SFRS1 interacting protein 1; gene trap 1, Heidi Sutherland
• MGI ID: MGI:3664569
• Synonyms: Psip1^-
• Gene: Psip1 Location: Chr4:83373917-83404696 bp, - strand Genetic Position: Chr4, 39.46 cM
• Alliance: Psip1^{Gt(betageo)1Hgs} page

Mutation origin

• Mutant Cell Line: ES149
• Germline Transmission: Earliest citation of germline transmission: J:112975
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector Type: gene trap
• Mutation details: A gene trap vector was inserted into intron 8. X-Gal staining failed to detect expression in preimplantation embryos, but detected ubiquitous expression in heterozygous embryos. RT-PCR failed to detect the full-length transcript in mutants. (J:112975)

Expression

In Mice Carrying this Mutation:	10 assay results
In Structures Affected by this Mutation:	25 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Psip1 Mutation: 30 strains or lines available

Notes

Mutant ES cell line = ES149, created in E14 ES cells.

References

• Original: J:112975 Sutherland HG, et al., Disruption of ledgf/psip1 results in perinatal mortality and homeotic skeletal transformations. Mol Cell Biol. 2006 Oct;26(19):7201-10
• All: 2 reference(s)