Cd4^del
Spontaneous Allele Detail

Summary

• Symbol: Cd4^del
• Name: CD4 antigen; deletion
• MGI ID: MGI:3664575
• Gene: Cd4 Location: Chr6:124841655-124865184 bp, - strand Genetic Position: Chr6, 59.17 cM
• Alliance: Cd4^del page

Mutation origin

• Strain of Origin: C57BR/cdJ

Mutation description

• Allele Type: Spontaneous
• Mutation: Intragenic deletion
• Mutation details: Sequence analysis revealed that one thymine was substituted for the 14 bp at the junction between exon VIII and intron VIII. This results in the skipping of exon 8 in the expressed transcript, resulting in a deletion of the transmembrane domain and C-terminus of the encoded protein. Soluble Cd4 is detectable in the sera of mutant mice. (J:46692)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cd4 Mutation: 85 strains or lines available

References

• Original: J:46692 Nagase H, et al., Novel mutant mice secreting soluble CD4 without expression of membrane-bound CD4. Eur J Immunol. 1998 Feb;28(2):403-12
• All: 2 reference(s)