Mr1^tm1Gfn
Targeted Allele Detail

Summary

• Symbol: Mr1^tm1Gfn
• Name: major histocompatibility complex, class I-related; targeted mutation 1, Susan Gilfillan
• MGI ID: MGI:3664578
• Synonyms: Mr1^-
• Gene: Mr1 Location: Chr1:155003620-155022560 bp, - strand Genetic Position: Chr1, 66.45 cM, cytoband H1
• Alliance: Mr1^tm1Gfn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:113083
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A vector was designed to delete a 1.4 kb region containing exons 2 and 3, which encode the alpha1 and alpha2 domains of the protein. Northern blot failed to detect transcript in mutant livers. (J:113083)

Expression

In Mice Carrying this Mutation:

104036 assay results 1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Mr1 Mutation: 28 strains or lines available

References

• Original: J:113083 Treiner E, et al., Selection of evolutionarily conserved mucosal-associated invariant T cells by MR1. Nature. 2003 Mar 13;422(6928):164-9
• All: 38 reference(s)