Dnai7^{Gt(VICTR21)709Lex}
Gene trapped Allele Detail

Summary

• Symbol: Dnai7^{Gt(VICTR21)709Lex}
• Name: dynein axonemal intermediate chain 7; gene trap 709, Lexicon Genetics
• MGI ID: MGI:3664581
• Synonyms: Casc1^ko
• Gene: Dnai7 Location: Chr6:145120560-145156731 bp, - strand Genetic Position: Chr6, 77.37 cM
• Alliance: Dnai7^{Gt(VICTR21)709Lex} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:111629
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Gene trapped (Null/knockout)
• Mutation: Insertion of gene trap vector
• Mutation details: A VICTR21 retroviral promoter trap was inserted into intron 10, inactivating Casc1. The integration physically splits the Casc1 gene by producing two fusion transcripts. The splice donor in VICTR21 is preceded by stop codons in all three reading frames to prevent expression of fusion transcripts. (J:111629)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dnai7 Mutation: 32 strains or lines available

References

• Original: J:111629 Liu P, et al., Candidate lung tumor susceptibility genes identified through whole-genome association analyses in inbred mice. Nat Genet. 2006 Aug;38(8):888-95
• All: 1 reference(s)