Neurog2^{tm5(Neurog2)Fgu}
Targeted Allele Detail

Summary

• Symbol: Neurog2^{tm5(Neurog2)Fgu}
• Name: neurogenin 2; targeted mutation 5, Francois Guillemot
• MGI ID: MGI:3664585
• Synonyms: Ngn2^{KIfloxNgn2flox}, Ngn2^KIloxNgn2
• Gene: Neurog2 Location: Chr3:127426784-127429280 bp, + strand Genetic Position: Chr3, 56.54 cM, cytoband H1
• Alliance: Neurog2^{tm5(Neurog2)Fgu} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:105298
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT-neo-FRT-loxP cassette was inserted in an intron 180bp 5' to the ATG of the Ngn2 gene. Five myc tags were inserted at the N-terminal end of the coding sequence and fused to the full length mouse coding sequence (minus the first codon). A loxP site was located 1.3 kb after the stop codon. (personal communication)

Expression

In Mice Carrying this Mutation:

6 assay results 1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Neurog2 Mutation: 18 strains or lines available

References

• Original: J:105298 Hand R, et al., Phosphorylation of Neurogenin2 specifies the migration properties and the dendritic morphology of pyramidal neurons in the neocortex. Neuron. 2005 Oct 6;48(1):45-62
• All: 5 reference(s)