Jak2^tm1Kf
Targeted Allele Detail

Summary

• Symbol: Jak2^tm1Kf
• Name: Janus kinase 2; targeted mutation 1, Kristen Frenzel
• MGI ID: MGI:3664597
• Gene: Jak2 Location: Chr19:29229228-29290480 bp, + strand Genetic Position: Chr19, 23.73 cM
• Alliance: Jak2^tm1Kf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:112700
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted
• Mutation: Nucleotide substitutions
• Mutation details: This allele contains the W1038G and E1046R mutations. The self-excising ACE-cre-neo cassette was included in the vector, just upstream of the active site mutations. (J:112700)

Expression

In Mice Carrying this Mutation:	2 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Jak2 Mutation: 59 strains or lines available

References

• Original: J:112700 Frenzel K, et al., A functional Jak2 tyrosine kinase domain is essential for mouse development. Exp Cell Res. 2006 Sep 10;312(15):2735-44
• All: 1 reference(s)