Col5a1^tm1Rjw
Targeted Allele Detail

Summary

• Symbol: Col5a1^tm1Rjw
• Name: collagen, type V, alpha 1; targeted mutation 1, Richard J Wenstrup
• MGI ID: MGI:3664598
• Synonyms: Col5a1^-, Col5a1^Neo, ColVa1-
• Gene: Col5a1 Location: Chr2:27776437-27929526 bp, + strand Genetic Position: Chr2, 19.38 cM, cytoband A2-B
• Alliance: Col5a1^tm1Rjw page

E10.5 Col5a1^tm1Rjw/Col5a1^tm1Rjw embryos exhibit blood pooling and absence of blood-filled vessels in yolk sacs

Show the 8 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:113133
• Parent Cell Line: KG-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Exon 3 and part of exon 4 were replaced with a neomycin resistance cassette. (J:113133)

Disease models

Expression

In Mice Carrying this Mutation:	29 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Col5a1 Mutation: 66 strains or lines available

References

• Original: J:113133 Wenstrup RJ, et al., Type V collagen controls the initiation of collagen fibril assembly. J Biol Chem. 2004 Dec 17;279(51):53331-7
• All: 8 reference(s)