Coro1a^tm1Achn
Targeted Allele Detail

Summary

• Symbol: Coro1a^tm1Achn
• Name: coronin, actin binding protein 1A; targeted mutation 1, Andrew C Chan
• MGI ID: MGI:3664599
• Synonyms: coronin 1^-
• Gene: Coro1a Location: Chr7:126298946-126303925 bp, - strand Genetic Position: Chr7, 69.25 cM, cytoband F3
• Alliance: Coro1a^tm1Achn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:111593
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2 through 10 were replaced with a neomycin resistance cassette. No Coro1a protein was detected in thymocytes, splenocytes, or bone marrow-derived cells. (J:111593)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Coro1a Mutation: 25 strains or lines available

References

• Original: J:111593 Foger N, et al., Requirement for coronin 1 in T lymphocyte trafficking and cellular homeostasis. Science. 2006 Aug 11;313(5788):839-42
• All: 4 reference(s)