Ercc2^tm3Jhjh
Targeted Allele Detail

Summary

• Symbol: Ercc2^tm3Jhjh
• Name: excision repair cross-complementing rodent repair deficiency, complementation group 2; targeted mutation 3, Jan H J Hoeijmakers
• MGI ID: MGI:3664604
• Synonyms: Xpd^G602D, Xpd^XPCS
• Gene: Ercc2 Location: Chr7:19115942-19129619 bp, + strand Genetic Position: Chr7, 9.62 cM
• Alliance: Ercc2^tm3Jhjh page

Microglia activation in the white matter in Ercc2, Ercc6, and Ercc8 mutants

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:112689
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Humanized sequence, Hypomorph)
• Mutation: Nucleotide substitutions
• Mutation details: A G602D point mutation was inserted with a loxP-flanked neo in the 3' UTR. The neo was subsequently removed via cre-mediated recombination. RT-PCR detected comparable expression between mutants and wild-types. (J:112689)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ercc2 Mutation: 23 strains or lines available

References

• Original: J:112689 Andressoo JO, et al., An Xpd mouse model for the combined xeroderma pigmentosum/Cockayne syndrome exhibiting both cancer predisposition and segmental progeria. Cancer Cell. 2006 Aug;10(2):121-32
• All: 6 reference(s)