Rr101^tm2Kio
Targeted Allele Detail

Summary

• Symbol: Rr101^tm2Kio
• Name: regulatory region 101; targeted mutation 2, Dimitris Kioussis
• MGI ID: MGI:3664645
• Synonyms: Cd8a^tm2Kio, CIII^delta1,2, delta1
• Gene: Rr101 Location: unknown Genetic Position: Chr6, Syntenic
• Alliance: Rr101^tm2Kio page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:110530
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Modified regulatory region, Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance gene replaced an 8 kb fragment containing the Cd8a cluster CIII DNaseI hypersensitivity sites CIII-1 and CIII-2. (J:110530)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr101 Mutation: 0 strains or lines available

References

• Original: J:110530 Hostert A, et al., Hierarchical interactions of control elements determine CD8alpha gene expression in subsets of thymocytes and peripheral T cells. Immunity. 1998 Oct;9(4):497-508
• All: 1 reference(s)