Cd8a^tm1.1Welm
Targeted Allele Detail

Summary

• Symbol: Cd8a^tm1.1Welm
• Name: CD8 subunit alpha; targeted mutation 1.1, Wilfried Ellmeier
• MGI ID: MGI:3664646
• Synonyms: delta2, E8ii
• Gene: Cd8a Location: Chr6:71350411-71356155 bp, + strand Genetic Position: Chr6, 32.14 cM, cytoband C
• Alliance: Cd8a^tm1.1Welm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:113136
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The neo selection cassette was removed in ES via tranfection with Cre recombinase, generating ES cells with only one loxP site. (J:113136)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cd8a Mutation: 39 strains or lines available

References

• Original: J:113136 Ellmeier W, et al., Combined deletion of CD8 locus cis-regulatory elements affects initiation but not maintenance of CD8 expression. Immunity. 2002 May;16(5):623-34
• All: 4 reference(s)