Ms4a2^tm1Knt
Targeted Allele Detail

Summary

• Symbol: Ms4a2^tm1Knt
• Name: membrane-spanning 4-domains, subfamily A, member 2; targeted mutation 1, Jean-Pierre Kinet
• MGI ID: MGI:3664659
• Synonyms: FcRbeta^-
• Gene: Ms4a2 Location: Chr19:11592887-11601083 bp, - strand Genetic Position: Chr19, 8.46 cM
• Alliance: Ms4a2^tm1Knt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:47138
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons IV-VI were replaced with a neomycin selection cassette. FceRI expression on bone marrowderived cultured mast cells was abolished in homozygous mice, indicating that this gene is required for cell surface expression of high-affinity IgE receptors. (J:47138)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ms4a2 Mutation: 12 strains or lines available

Notes

ES cell line = D3 (129S2/SvPas) or E14Tg2a (129P2/OlaHsd).

References

• Original: J:47138 Dombrowicz D, et al., Allergy-associated FcRbeta is a molecular amplifier of IgE- and IgG-mediated in vivo responses. Immunity. 1998 Apr;8(4):517-29
• All: 1 reference(s)