Gas6^tm1Hiar
Targeted Allele Detail

Summary

• Symbol: Gas6^tm1Hiar
• Name: growth arrest specific 6; targeted mutation 1, Hidenori Arai
• MGI ID: MGI:3664768
• Synonyms: Gas6^-
• Gene: Gas6 Location: Chr8:13515374-13544490 bp, - strand Genetic Position: Chr8, 6.06 cM
• Alliance: Gas6^tm1Hiar page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:112430
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The exon encoding the ATG was replaced with a neomycin resistance cassette. Transcript and protein were absent in mutant analyzed by Northern and Western blotting, respectively. (J:112430)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Gas6^tm1Hiar

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gas6 Mutation: 36 strains or lines available

References

• Original: J:112430 Yanagita M, et al., Essential role of Gas6 for glomerular injury in nephrotoxic nephritis. J Clin Invest. 2002 Jul;110(2):239-46
• All: 4 reference(s)