Nodal^tm1.1Dbc
Targeted Allele Detail

Summary

• Symbol: Nodal^tm1.1Dbc
• Name: nodal growth differentiation factor; targeted mutation 1.1, Daniel B Constam
• MGI ID: MGI:3664774
• Synonyms: Nodal^Nr
• Gene: Nodal Location: Chr10:61253751-61261117 bp, + strand Genetic Position: Chr10, 32.21 cM
• Alliance: Nodal^tm1.1Dbc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:112799
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: Cre mediated recombination of Nodal^tm1Dbc resulted in removal of the PGK-hygro cassette and wild-type exons 2 and 3, leaving behind just the cleavage resistant mutant exons 2 and 3. (J:112799)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nodal Mutation: 42 strains or lines available

References

• Original: J:112799 Ben-Haim N, et al., The nodal precursor acting via activin receptors induces mesoderm by maintaining a source of its convertases and BMP4. Dev Cell. 2006 Sep;11(3):313-23
• All: 1 reference(s)