Sfrp2tm1Sato
Targeted Allele Detail
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Symbol: |
Sfrp2tm1Sato |
Name: |
secreted frizzled-related protein 2; targeted mutation 1, Thomas N Sato |
MGI ID: |
MGI:3664776 |
Synonyms: |
sFRP2lacZ |
Gene: |
Sfrp2 Location: Chr3:83673628-83681621 bp, + strand Genetic Position: Chr3, 37.37 cM
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Alliance: |
Sfrp2tm1Sato page
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Germline Transmission: |
Earliest citation of germline transmission:
J:112802
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
Not Specified
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Allele Type: |
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Targeted (Null/knockout, Reporter) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: The first coding exon was replaced with lacZ via homologous recombination. The selection cassette was removed by crossing mice to germline Cre expressing mice.
(J:112802)
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Key: |
hm |
homozygous |
ht |
heterozygous |
tg |
involves transgenes |
√ |
phenotype observed |
cn |
conditional genotype |
cx |
complex: > 1 genome feature |
ot |
other: hemizygous, indeterminate,... |
N |
normal phenotype |
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Genotype/ Background: |
| Allelic Composition | Genetic Background | Cell Line(s) |
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Loading... | | | Not Specified | |
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Phenotypes: |
Affected Systems |
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cardiovascular system
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√
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increased cardiac muscle contractility
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√
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abnormal response of heart to induced stress
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√
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cellular
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√
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abnormal neuron differentiation
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√
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homeostasis/metabolism
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√
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abnormal response of heart to induced stress
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√
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muscle
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√
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increased cardiac muscle contractility
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√
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nervous system
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√
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abnormal neuron differentiation
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√
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Sfrp2 Mutation: |
30 strains or lines available
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Original: |
J:112802 Lei Q, et al., Wnt signaling inhibitors regulate the transcriptional response to morphogenetic Shh-Gli signaling in the neural tube. Dev Cell. 2006 Sep;11(3):325-37 |
All: |
4 reference(s) |
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