Sbds^tm1Jrom
Targeted Allele Detail

Summary

• Symbol: Sbds^tm1Jrom
• Name: SBDS ribosome maturation factor; targeted mutation 1, Johanna M Rommens
• MGI ID: MGI:3664792
• Synonyms: S^-
• Gene: Sbds Location: Chr5:130274573-130284371 bp, - strand Genetic Position: Chr5, 68.97 cM
• Alliance: Sbds^tm1Jrom page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:112167
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: Exon 1 was disrupted through insertion of an IRES-lacZ and neo cassette. In situ hybridization analysis confirmed the absence of mRNA in E6.5 homozygous embryos. (J:112167)

Disease models

Expression

In Mice Carrying this Mutation:	8 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sbds Mutation: 31 strains or lines available

References

• Original: J:112167 Zhang S, et al., Loss of the mouse ortholog of the shwachman-diamond syndrome gene (Sbds) results in early embryonic lethality. Mol Cell Biol. 2006 Sep;26(17):6656-63
• All: 5 reference(s)