Nhdlq9^DBA/2J
QTL Variant Detail

Summary

• QTL variant: Nhdlq9^DBA/2J
• Name: non-HDL QTL 9; DBA/2J
• MGI ID: MGI:3664913
• QTL: Nhdlq9 Location: unknown Genetic Position: Chr15, cM position of peak correlated region/allele: 45.02 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: DBA/2J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased non-HDL cholesterol compared to PERA/EiJ. (J:112668)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:112668

To identify loci that influence lipo-protein cholesterol levels QTL mapping was performed on PERA/EiJ x I/LnJ and PERA/EiJ x DBA/2J intercrosses and in a combined data set from both crosses. Parental strain PERA/EiJ exhibits increased HDL cholesterol compared to I/LnJ and DBA/2J after 8 weeks on the high fat diet, while parental strain I/LnJ exhibits increased non-HDL cholesterol compared to PERA/EiJ and DBA/2J.

LOD scores for HDL cholesterol concentrations were considered significant when exceeding 2.9in each of the PERA intercrosses. A LOD score of 3.0 or better was the threshold for significance in the combined cross data when the cross was an additive covariate; 3.7 when the cross was an interactive covariate. The analysis of combined data from bothcrosses increased the detection power of the analysis.

Significant linkage to non-HDL cholesterol mapped to 56.0 cM near D15Mit171 in the (PERA/EiJ x DBA/2J)F2 cross, LOD=3.3. The LOD score increased to 4.0 when data from both crosses were combined and the cross was considered as an interactive covariate.This locus is named Nhdlq9 (non-HDL QTL 9). The QTL interval spans 44cM - 62 cM. DBA/2J-derived alleles at Nhdlq9 confer increased non-HDL cholesterol.

References

• Original: J:112668 Wittenburg H, et al., QTL mapping for genetic determinants of lipoprotein cholesterol levels in combined crosses of inbred mouse strains. J Lipid Res. 2006 Aug;47(8):1780-90
• All: 1 reference(s)