Nhdlq10^PERA/EiJ
QTL Variant Detail

Summary

• QTL variant: Nhdlq10^PERA/EiJ
• Name: non-HDL QTL 10; PERA/EiJ
• MGI ID: MGI:3664915
• QTL: Nhdlq10 Location: Chr16:7263744-7263853 bp Genetic Position: Chr16, cM position of peak correlated region/allele: 3.43 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: PERA/EiJ

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased non-HDL cholesterol compared to I/LnJ. (J:112668)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:112668

To identify loci that influence lipo-protein cholesterol levels QTL mapping was performed on PERA/EiJ x I/LnJ and PERA/EiJ x DBA/2J intercrosses and in a combined data set from both crosses. Parental strain PERA/EiJ exhibits increased HDL cholesterol compared to I/LnJ and DBA/2J after 8 weeks on the high fat diet, while parental strain I/LnJ exhibits increased non-HDL cholesterol compared to PERA/EiJ and DBA/2J.

LOD scores for HDL cholesterol concentrations were considered significant when exceeding 2.9in each of the PERA intercrosses. A LOD score of 3.0 or better was the threshold for significance in the combined cross data when the cross was an additive covariate; 3.7 when the cross was an interactive covariate. The analysis of combined data from bothcrosses increased the detection power of the analysis.

Significant linkage to non-HDL cholesterol mapped to 4.0 cM near marker D16Mit122 in the (PERA/EiJ x I/LnJ)F2 cross, LOD=3.2, and is named Nhdlq10 (non-HDL QTL 8). The Nhdlq10 QTL interval spans 0cM- 14cM. The LOD increased to 3.9 in the combined cross data when cross was considered as an additive covariate. Higher levels of non-HDL cholesterol was associated with the allele from the PERA/EiJ strain at this locus.

References

• Original: J:112668 Wittenburg H, et al., QTL mapping for genetic determinants of lipoprotein cholesterol levels in combined crosses of inbred mouse strains. J Lipid Res. 2006 Aug;47(8):1780-90
• All: 1 reference(s)