Mrtfa^tm1Swm
Targeted Allele Detail

Summary

• Symbol: Mrtfa^tm1Swm
• Name: myocardin related transcription factor A; targeted mutation 1, Stephan W Morris
• MGI ID: MGI:3665132
• Gene: Mrtfa Location: Chr15:80896482-81074937 bp, - strand Genetic Position: Chr15, 37.98 cM
• Alliance: Mrtfa^tm1Swm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:111560
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced exons 9-14. Western blotting analysis of lysates from MEFs isolated from E13.5 embryos revealed the complete absence of detectable protein expression from this allele. (J:111560)

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mrtfa Mutation: 32 strains or lines available

References

• Original: J:111560 Sun Y, et al., Acute myeloid leukemia-associated Mkl1 (Mrtf-a) is a key regulator of mammary gland function. Mol Cell Biol. 2006 Aug;26(15):5809-26
• All: 10 reference(s)