Adora2b^tm1Kra
Targeted Allele Detail

Summary

• Symbol: Adora2b^tm1Kra
• Name: adenosine A2b receptor; targeted mutation 1, Katya Ravid
• MGI ID: MGI:3665133
• Synonyms: A2bAR-null
• Gene: Adora2b Location: Chr11:62139810-62157278 bp, + strand Genetic Position: Chr11, 37.96 cM, cytoband B2
• Alliance: Adora2b^tm1Kra page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:111715
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1, including the initiation codon, was replaced with a reporter construct containing a lacZ gene, stop codon and poly(A) signal. RNA transcripts were quantified in various tissues using RT-PCR to confirm gene ablation. Beta-galactosidase expression is observed in the vasculature of all major organ systems tested. Some ectopic expression is also noted. (J:111715, J:199685)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adora2b Mutation: 21 strains or lines available

References

• Original: J:111715 Yang D, et al., The A2B adenosine receptor protects against inflammation and excessive vascular adhesion. J Clin Invest. 2006 Jul;116(7):1913-23
• All: 31 reference(s)