Fbxw8^tm1Kei
Targeted Allele Detail

Summary

• Symbol: Fbxw8^tm1Kei
• Name: F-box and WD-40 domain protein 8; targeted mutation 1, Kenichi I Nakayama
• MGI ID: MGI:3665136
• Gene: Fbxw8 Location: Chr5:118203046-118293523 bp, - strand Genetic Position: Chr5, 57.92 cM, cytoband F
• Alliance: Fbxw8^tm1Kei page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:111403
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2, which encodes the NH2 terminus of the encoded protein, was replaced with IRES-lacZ and PGK-neo-poly(A)-loxP cassettes. Immunoblot analysis revealed that no encoded protein was detectable in homozygous mutant embryos or in the corresponding placentas. (J:111403)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fbxw8 Mutation: 30 strains or lines available

References

• Original: J:111403 Tsunematsu R, et al., Fbxw8 is essential for Cul1-Cul7 complex formation and for placental development. Mol Cell Biol. 2006 Aug;26(16):6157-69
• All: 3 reference(s)