Brca1^tm4Cxd
Targeted Allele Detail

Summary

• Symbol: Brca1^tm4Cxd
• Name: breast cancer 1, early onset; targeted mutation 4, Chu-Xia Deng
• MGI ID: MGI:3665173
• Synonyms: Brca1^FL
• Gene: Brca1 Location: Chr11:101379590-101442781 bp, - strand Genetic Position: Chr11, 65.18 cM, cytoband D
• Alliance: Brca1^tm4Cxd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:112308
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Hypomorph, Inserted expressed sequence, Modified isoform(s))
• Mutation: Insertion
• Mutation details: A gene fragment including part of exon 11 and all of intron 11 and exon 12 was replaced with a cDNA that results in joining of exon 11 to all exons 3' of exon 11. RT-PCR and Northern blot analysis confirmed the absence of transcript of the alternative splicing form of Brca1 that lacks exon 11; however, full length transcript is present. (J:112308)

Tumor Data

List all tumor models in MMHCdb carrying Brca1^tm4Cxd

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Brca1 Mutation: 114 strains or lines available

References

• Original: J:112308 Kim SS, et al., Hyperplasia and spontaneous tumor development in the gynecologic system in mice lacking the BRCA1-Delta11 isoform. Mol Cell Biol. 2006 Sep;26(18):6983-92
• All: 1 reference(s)