Chlq18^C3H/HeJ
QTL Variant Detail

Summary

• QTL variant: Chlq18^C3H/HeJ
• Name: circulating hormone level QTL 18; C3H/HeJ
• MGI ID: MGI:3665213
• QTL: Chlq18 Location: Chr7:58148820-58148965 bp Genetic Position: Chr7, cM position of peak correlated region/allele: 33.88 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: C3H/HeJ

Variant description

• Allele Type: QTL

Notes

Chlq18 exhibits paternal inheritance.

This allele participates in epistatic interactions with Chlq15, Chlq16, and Chlq17.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:111693

A population of 961 animals from a (C3H/HeJ x DBA/2J)F1 x (BALB/cJ x C57BL/6J)F1 cross were previously analyzed for genetic linkage to serum IGF levels. A new analysis was performed using the Hanlon-Lorenz random walk method to identify loci involved in epistatic interactions. Animals were phenotyped for serum IGF at 4 months of age. Polymorphic markers at an average resolution of 15 cM - 20 cM were used for the genome scan.

A three-way interaction was detected involving loci on mouse Chromosome 5, 17,and 18. The chromosome 17 locus at D17Mit185 (40.6 cM) is of maternal origin and is designated Chlq9 (circulating hormone level QTL 9). The loci at D18Mit55 (25 cM) and D5Mit95 (68 cM) are of paternal origin and are designated Chlq10 and Chlq11, respectively. Inheritance of BALB/cJ-derived alleles at Chlq9 with C3H/HeJ- or DBA/2J-derived alleles at both Chlq10 and Chlq11 confer increased serum IGF. In contrast, inheritance of C57BL/6J-derived alleles at Chlq9 and DBA/2J-derived alleles at both Chlq10 andChlq11 conferdecreased serum IGF.

Chlq9 and Chlq11 are also involved in a four-way interaction with loci on chromosomes 7 and 8. The chromosome 7 locus at D7Mit25 (16 cM) is of paternal origin and is designated Chlq12 (circulating hormone level QTL 12).The chromosome 8 locus at D8Mit51 (41 cM) is of maternal origin, and was identified previously as Chlq5 (circulating hormone level QTL 5). Inheritance of DBA/2J-derived alleles at Chlq11 and Chlq12 in conjunction with C57BL/6J-derived alleles at Chlq9, and BALB/cJ-derived alleles at Chlq5 confer decreased serum IGF.

A four-way interaction was detected between loci on chromosome 8, 2, 5, and 10. Chlq13 (circulating hormone level QTL 13) at D2Mit285 (86 cM), Chlq14 at D5Mit205 (45 cM), and Chlq15 at D10Mit230 (49 cM) are of paternal origin. Chlq5 at D8Mit51 (41 cM) is of maternal origin. Inheritance of DBA/2J-derived alleles at Chlq14 and Chlq13 in conjunction with C3H/HeJ-derived alleles at Chlq15 and C57BL/6J-derived alleles at Chlq5 confer increased serumIGF.

A four-way interaction was detected between loci on chromosomes 4, 7, 10, and 12. Chlq16 (circulating hormone level QTL 16) at D4Mit170 (66.6 cM) and Chlq17 at D12Mit167 (52 cM) are maternally-inherited, and Chlq18 at D7Mit91 (28.1 cM) and Chlq15 atD10Mit230 are paternally inherited. C3H/HeJ-derived alleles at Chlq18 and Chlq15 in conjunction with BALB/cJ-derived alleles at Chlq17 and Chlq16 confer increased serum IGF.

References

• Original: J:111693 Hanlon P, et al., Three-locus and four-locus QTL interactions influence mouse insulin-like growth factor-I. Physiol Genomics. 2006 Jun 16;26(1):46-54
• All: 1 reference(s)