Gt(ROSA)26Sor^{tm1(MAML1)Wsp}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(MAML1)Wsp}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Warren S Pear
• MGI ID: MGI:3665249
• Synonyms: DNMAML1^f, DNMAML1-GFP, Mam1^DN, R26^flDNM-GFP, ROSA26-DNMAML, ROSA26^DNMAMLf
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(MAML1)Wsp} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:113262
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, Humanized sequence, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1(MAML1)Wsp} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  MAML1 (9794)

  Maml1

  (MGI:1890504)

• Mutation details: A pgk-neo-pA cassette was flanked by loxP sites was placed upstream of cDNA for Drosophila MAML1 fused to a GFP-bpA. The cDNA contained amino acids 13-74 of MAML1 and expression is allowed upon removal of the neo. (J:113262)

Disease models

Expression

In Structures Affected by this Mutation:

11 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Gt(ROSA)26Sor^{tm1(MAML1)Wsp}

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 993 strains or lines available

References

• Original: J:113262 Tu L, et al., Notch signaling is an important regulator of type 2 immunity. J Exp Med. 2005 Oct 17;202(8):1037-42
• All: 64 reference(s)