Jak3^X887Y
Spontaneous Allele Detail

Summary

• Symbol: Jak3^X887Y
• Name: Janus kinase 3; X887Y
• MGI ID: MGI:3665252
• Gene: Jak3 Location: Chr8:72129027-72143221 bp, + strand Genetic Position: Chr8, 34.43 cM
• Alliance: Jak3^X887Y page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Spontaneous
• Mutation: Single point mutation
• Mutation details: This mutation corresponds to a T to A point mutation in the sequences encoding the kinase-1 domain, and thus generated a stop codon in place of a codon encoding for tyrosine 887. This mutation abrogates the expression of Jak3 protein. (J:112658)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Jak3 Mutation: 84 strains or lines available

References

• Original: J:112658 Prinz I, et al., Visualization of the earliest steps of gammadelta T cell development in the adult thymus. Nat Immunol. 2006 Sep;7(9):995-1003
• All: 1 reference(s)