Cryaa^L1N
Chemically induced Allele Detail

Summary

• Symbol: Cryaa^L1N
• Name: crystallin, alpha A; L1N
• MGI ID: MGI:3665274
• Synonyms: alphaA^Y118D
• Gene: Cryaa Location: Chr17:31896905-31900704 bp, + strand Genetic Position: Chr17, 17.09 cM, cytoband A3-B
• Alliance: Cryaa^L1N page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: Sequencing analysis revealed that a T-to-G tranversion mutation occurred which resulted in the substitution of the tyrosine residue at codon 118 by an aspartic acid in the encoded protein. (J:112248)
• Inheritance: Dominant

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cryaa Mutation: 15 strains or lines available

References

• Original: J:112248 Xia CH, et al., Arginine 54 and Tyrosine 118 residues of {alpha}A-crystallin are crucial for lens formation and transparency. Invest Ophthalmol Vis Sci. 2006 Jul;47(7):3004-10
• All: 2 reference(s)