Rock1^tm1Liao
Targeted Allele Detail

Summary

• Symbol: Rock1^tm1Liao
• Name: Rho-associated coiled-coil containing protein kinase 1; targeted mutation 1, James K Liao
• MGI ID: MGI:3665285
• Synonyms: Rock1^-, Rock I^-
• Gene: Rock1 Location: Chr18:10064401-10182045 bp, - strand Genetic Position: Chr18, 4.91 cM, cytoband A2
• Alliance: Rock1^tm1Liao page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:112242
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exon 1b was removed via cre-mediated recombination, resulting in a frame shift that created a stop codon in exon 1c, preventing translation of the functional protein. (J:112242)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rock1 Mutation: 60 strains or lines available

References

• Original: J:112242 Rikitake Y, et al., Rho-kinase mediates hyperglycemia-induced plasminogen activator inhibitor-1 expression in vascular endothelial cells. Circulation. 2005 Jun 21;111(24):3261-8
• All: 13 reference(s)