Ptch2^tm1Pmc
Targeted Allele Detail

Summary

• Symbol: Ptch2^tm1Pmc
• Name: patched 2; targeted mutation 1, Peter J McKinnon
• MGI ID: MGI:3665289
• Synonyms: Ptch2^-
• Gene: Ptch2 Location: Chr4:116953272-116973298 bp, + strand Genetic Position: Chr4, 53.41 cM, cytoband C-D
• Alliance: Ptch2^tm1Pmc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:112118
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exons 5-17 were removed from the locus by cre mediated recombination. RT-PCR confirmed absence of transcript encoded by this sequence. (J:112118)

Disease models

Tumor Data

List all tumor models in MMHCdb carrying Ptch2^tm1Pmc

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptch2 Mutation: 47 strains or lines available

References

• Original: J:112118 Lee Y, et al., Patched2 modulates tumorigenesis in patched1 heterozygous mice. Cancer Res. 2006 Jul 15;66(14):6964-71
• All: 3 reference(s)