Pot1a^tm1Schg
Targeted Allele Detail

Summary

• Symbol: Pot1a^tm1Schg
• Name: protection of telomeres 1A; targeted mutation 1, Sandy Chang
• MGI ID: MGI:3665306
• Synonyms: Pot1a^rec
• Gene: Pot1a Location: Chr6:25743939-25809280 bp, - strand Genetic Position: Chr6, 11.65 cM
• Alliance: Pot1a^tm1Schg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:112184
• Parent Cell Line: AB2.1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted to flank exons 4 and 5. Exon 4 contains the ATG and exon 5 contains a portion of the protein critical for telomere binding. (J:112184)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pot1a Mutation: 42 strains or lines available

References

• Original: J:112184 Wu L, et al., Pot1 deficiency initiates DNA damage checkpoint activation and aberrant homologous recombination at telomeres. Cell. 2006 Jul 14;126(1):49-62
• All: 6 reference(s)