Gabpa^tm1Sjb
Targeted Allele Detail

Summary

• Symbol: Gabpa^tm1Sjb
• Name: GA repeat binding protein, alpha; targeted mutation 1, Steven J Burden
• MGI ID: MGI:3665312
• Synonyms: Gabpalpha^f
• Gene: Gabpa Location: Chr16:84631813-84660667 bp, + strand Genetic Position: Chr16, 46.92 cM, cytoband C3-4
• Alliance: Gabpa^tm1Sjb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:121823
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: LoxP sites were introduced into introns 7 and 9 and and frt-flanked neomycin resistance cassette was inserted within the loxP-flanked region in intron 9. The neomycin resistance cassette was removed by crossing to Flp- expressing mice, leaving only the loxP sites that flank sequences corresponding to the DNA-binding region of the encoded protein. (J:121823)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gabpa Mutation: 67 strains or lines available

References

• Original: J:121823 Jaworski A, et al., GA-Binding Protein Is Dispensable for Neuromuscular Synapse Formation and Synapse-Specific Gene Expression. Mol Cell Biol. 2007 Jul;27(13):5040-6
• All: 5 reference(s)