Sele^tm1Dmil
Targeted Allele Detail

Summary

• Symbol: Sele^tm1Dmil
• Name: selectin, endothelial cell; targeted mutation 1, David Milstone
• MGI ID: MGI:3665314
• Synonyms: E^-, E-selectin^-
• Gene: Sele Location: Chr1:163875773-163885246 bp, + strand Genetic Position: Chr1, 71.35 cM
• Alliance: Sele^tm1Dmil page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:113169
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The neomycin resistance gene was substituted in reverse transcriptional orientation for sequence spanning from exon 1 to exon 3. Northern blot confirmed absence of transcript in mutant kidney, lung and heart samples. (J:113169)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Sele Mutation: 51 strains or lines available

References

• Original: J:113169 Milstone DS, et al., Mice lacking E-selectin show normal numbers of rolling leukocytes but reduced leukocyte stable arrest on cytokine-activated microvascular endothelium. Microcirculation. 1998;5(2-3):153-71
• All: 8 reference(s)