Wt1^tm2.1Vih
Targeted Allele Detail

Summary

• Symbol: Wt1^tm2.1Vih
• Name: WT1 transcription factor; targeted mutation 2.1, Vicki Huff
• MGI ID: MGI:3665321
• Synonyms: Wt1^delta
• Gene: Wt1 Location: Chr2:104956874-105003959 bp, + strand Genetic Position: Chr2, 55.06 cM, cytoband E
• Alliance: Wt1^tm2.1Vih page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:111787
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele is a derivative of Wt1^tm2Vih in which the floxed exons 8 and 9 were deleted by using an oocyte-specific Zp3-cre transgene, resulting in a shortened protein lacking zinc fingers 2 and 3. (J:111787)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Wt1 Mutation: 34 strains or lines available

References

• Original: J:111787 Gao F, et al., The Wilms tumor gene, Wt1, is required for Sox9 expression and maintenance of tubular architecture in the developing testis. Proc Natl Acad Sci U S A. 2006 Aug 8;103(32):11987-92
• All: 1 reference(s)