Grm3^tm1Ddsc
Targeted Allele Detail

Summary

• Symbol: Grm3^tm1Ddsc
• Name: glutamate receptor, metabotropic 3; targeted mutation 1, Darryle D Schoepp
• MGI ID: MGI:3665324
• Synonyms: mGlu3^-, mGluR3-KO
• Gene: Grm3 Location: Chr5:9535541-9775170 bp, - strand Genetic Position: Chr5, 3.69 cM
• Alliance: Grm3^tm1Ddsc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:113260
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance gene replaced most of the third exon that encodes for a large portion of the ligand-binding domain. (J:113260)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Grm3 Mutation: 54 strains or lines available

References

• Original: J:113260 Linden AM, et al., Anxiolytic-like activity of the mGLU2/3 receptor agonist LY354740 in the elevated plus maze test is disrupted in metabotropic glutamate receptor 2 and 3 knock-out mice. Psychopharmacology (Berl). 2005 Apr;179(1):284-91
• All: 10 reference(s)