Th^tm1Gfng
Targeted Allele Detail

Summary

• Symbol: Th^tm1Gfng
• Name: tyrosine hydroxylase; targeted mutation 1, Guoping Feng
• MGI ID: MGI:3665325
• Synonyms: TH^YFP
• Gene: Th Location: Chr7:142446516-142453732 bp, - strand Genetic Position: Chr7, 88.06 cM
• Alliance: Th^tm1Gfng page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:113138
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to replace exon 1, intron 1 and the first 15 bp of exon 2 with cDNA encoding YFP and a floxed PGK-neo cassette. Transient expression of cre recombinase removed the neo cassette. (J:113138)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Th Mutation: 58 strains or lines available

References

• Original: J:113138 Kelly BB, et al., A tyrosine hydroxylase-yellow fluorescent protein knock-in reporter system labeling dopaminergic neurons reveals potential regulatory role for the first intron of the rodent tyrosine hydroxylase gene. Neuroscience. 2006 Oct 13;142(2):343-54
• All: 1 reference(s)