Pot1a^{Gt(RRA096)Byg}
Gene trapped Allele Detail

Summary

• Symbol: Pot1a^{Gt(RRA096)Byg}
• Name: protection of telomeres 1A; gene trap RRA096, BayGenomics
• MGI ID: MGI:3665328
• Synonyms: POT1a^8GEO
• Gene: Pot1a Location: Chr6:25743939-25809280 bp, - strand Genetic Position: Chr6, 11.65 cM
• Alliance: Pot1a^{Gt(RRA096)Byg} page

Mutation origin

• Mutant Cell Line: RRA096
• Germline Transmission: Earliest citation of germline transmission: J:112185
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: pGT1Lxf Vector Type: gene trap
• Mutation details: A beta-geo trap vector was inserted into intron 8 of the locus. Homozygosity for this allele is embryonic lethal. (J:112185)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  RRA096	CC183555 ; (MGI Seq Detail)	5' RACE	Chr6:25757223-25771543 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  10 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Mice Carrying this Mutation:	3 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pot1a Mutation: 42 strains or lines available

Notes

All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

References

• Original: J:112185 Hockemeyer D, et al., Recent expansion of the telomeric complex in rodents: Two distinct POT1 proteins protect mouse telomeres. Cell. 2006 Jul 14;126(1):63-77
• All: 2 reference(s)