Pot1b^tm1Tdl
Targeted Allele Detail

Summary

• Symbol: Pot1b^tm1Tdl
• Name: protection of telomeres 1B; targeted mutation 1, Titia de Lange
• MGI ID: MGI:3665333
• Synonyms: POT1b^STOP
• Gene: Pot1b Location: Chr17:55958951-56019628 bp, - strand Genetic Position: Chr17, 28.93 cM, cytoband D
• Alliance: Pot1b^tm1Tdl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:112185
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to insert a floxed neo and an FRT-flanked puro-STOP cassette upstream of the third coding exon. A third loxP site was inserted downstream of the third coding exon. (J:112185)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pot1b Mutation: 38 strains or lines available

References

• Original: J:112185 Hockemeyer D, et al., Recent expansion of the telomeric complex in rodents: Two distinct POT1 proteins protect mouse telomeres. Cell. 2006 Jul 14;126(1):63-77
• All: 4 reference(s)