Gabbr1^tm4Bet
Targeted Allele Detail

Summary

• Symbol: Gabbr1^tm4Bet
• Name: gamma-aminobutyric acid type B receptor subunit 1; targeted mutation 4, Bernhard Bettler
• MGI ID: MGI:3665433
• Synonyms: 1b^-, GABAB(1b)^-, GABAB1b^-, GB1b^-
• Gene: Gabbr1 Location: Chr17:37356888-37385197 bp, + strand Genetic Position: Chr17, 19.16 cM
• Alliance: Gabbr1^tm4Bet page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:113340
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: BALB/c

Mutation description

• Allele Type: Targeted (Modified isoform(s))
• Mutation: Nucleotide substitutions
• Mutation details: The start codon for the B1b isoform of Gabbr1 was converted into a stop codon to prevent translation of the B1b isoform. A floxed neomycin cassette was inserted in the introns between exons 5a and 1b. The neomycin cassette was removed by crossing with mice expressing Cre-recombinase under the control of the cytomegalus virus promoter. Northern blot analysis confirmed absence of the B1b isoform. (J:113340)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gabbr1 Mutation: 73 strains or lines available

References

• Original: J:113340 Vigot R, et al., Differential compartmentalization and distinct functions of GABAB receptor variants. Neuron. 2006 May 18;50(4):589-601
• All: 17 reference(s)