Gzmm^tm1(cre)Mjs
Targeted Allele Detail

Summary

• Symbol: Gzmm^tm1(cre)Mjs
• Name: granzyme M (lymphocyte met-ase 1); targeted mutation 1, Mark J Smyth
• MGI ID: MGI:3665444
• Synonyms: GrzM^-, GrzM cre
• Gene: Gzmm Location: Chr10:79524854-79531095 bp, + strand Genetic Position: Chr10, 39.72 cM, cytoband C
• Alliance: Gzmm^tm1(cre)Mjs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:113213
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Gzmm^tm1(cre)Mjs expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Gzmm (MGI:99549)

• Mutation details: Cre recombinase cDNA was inserted directly upstream of the ATG in exon 1. An frt-flanked neo was included in the vector and was removed in vivo. RT-PCR demonstrated expression of cre in the mutant mice and the absence of full-length Gzmm transcript in mutants. (J:113213)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Gzmm (mouse) Summary of all recombinase alleles driven by Gzmm. Alliance mouse Gzmm gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gzmm Mutation: 7 strains or lines available

References

• Original: J:113213 Pao LI, et al., Functional analysis of granzyme M and its role in immunity to infection. J Immunol. 2005 Sep 1;175(5):3235-43
• All: 5 reference(s)