Notch1^tm1Pst
Targeted Allele Detail

Summary

• Symbol: Notch1^tm1Pst
• Name: notch 1; targeted mutation 1, Pamela Stanley
• MGI ID: MGI:3665446
• Synonyms: Notch1^-
• Gene: Notch1 Location: Chr2:26347914-26393834 bp, - strand Genetic Position: Chr2, 18.91 cM
• Alliance: Notch1^tm1Pst page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:112097
• Parent Cell Line: WW6 (ES Cell)
• Strain of Origin: STOCK 129/Sv and C57BL/6J and SJL

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Disruption caused by insertion of vector
• LoxP sites were inserted to flank exons 6-8. (J:112097)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Notch1 Mutation: 117 strains or lines available

References

• Original: J:112097 Stahl M, et al., Notch1-induced transformation of RKE-1 cells requires up-regulation of cyclin D1. Cancer Res. 2006 Aug 1;66(15):7562-70
• All: 1 reference(s)