Gbx2^tm1Mrt
Targeted Allele Detail

Summary

• Symbol: Gbx2^tm1Mrt
• Name: gastrulation brain homeobox 2; targeted mutation 1, Gail R Martin
• MGI ID: MGI:3665450
• Synonyms: Gbx2^flox
• Gene: Gbx2 Location: Chr1:89855684-89858898 bp, - strand Genetic Position: Chr1, 45.06 cM, cytoband C5-E1
• Alliance: Gbx2^tm1Mrt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:42110
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, Hypomorph)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted to flank exon 2, with a neo cassette upstream of the 5' loxP site. Aberrantly spliced transcripts were detected in these mutants. (J:42110)

Expression

In Mice Carrying this Mutation:

58 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gbx2 Mutation: 27 strains or lines available

References

• Original: J:42110 Wassarman KM, et al., Specification of the anterior hindbrain and establishment of a normal mid/hindbrain organizer is dependent on Gbx2 gene function. Development. 1997 Aug;124(15):2923-34
• All: 6 reference(s)