Pla2r1^tm1Itoh
Targeted Allele Detail

Summary

• Symbol: Pla2r1^tm1Itoh
• Name: phospholipase A2 receptor 1; targeted mutation 1, Takeshi Itoh
• MGI ID: MGI:3686614
• Synonyms: PLA2R-deficient
• Gene: Pla2r1 Location: Chr2:60247887-60383652 bp, - strand Genetic Position: Chr2, 34.65 cM
• Alliance: Pla2r1^tm1Itoh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:44868
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance gene replaced exon 1 and flanking sequences, including the translation starting codon. Northern blot analysis revealed the transcript present in the lung, kidney, and ovary in control mice, but absent in the homozygous mutant mice. (J:44868)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Pla2r1^tm1Itoh

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pla2r1 Mutation: 74 strains or lines available

References

• Original: J:44868 Hanasaki K, et al., Resistance to endotoxic shock in phospholipase A2 receptor-deficient mice. J Biol Chem. 1997 Dec 26;272(52):32792-7
• All: 9 reference(s)