Aifm1^tm2Pngr
Targeted Allele Detail

Summary

• Symbol: Aifm1^tm2Pngr
• Name: apoptosis-inducing factor, mitochondrion-associated 1; targeted mutation 2, Josef M Penninger
• MGI ID: MGI:3686777
• Synonyms: Aif^flox
• Gene: Aifm1 Location: ChrX:47563821-47602440 bp, - strand Genetic Position: ChrX, 25.68 cM, cytoband A6
• Alliance: Aifm1^tm2Pngr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:113016
• Parent Cell Line: E14TG2a.4 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to flank exon 7, which encodes amino acids 232 to 259. Deletion of the sequence disrupts the reading frame. (J:113016)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Aifm1 Mutation: 10 strains or lines available

References

• Original: J:113016 Joza N, et al., Muscle-specific loss of apoptosis-inducing factor leads to mitochondrial dysfunction, skeletal muscle atrophy, and dilated cardiomyopathy. Mol Cell Biol. 2005 Dec;25(23):10261-72
• All: 11 reference(s)