Arhgef1^tm1.1Rmt
Targeted Allele Detail

Summary

• Symbol: Arhgef1^tm1.1Rmt
• Name: Rho guanine nucleotide exchange factor 1; targeted mutation 1.1, Raul M Torres
• MGI ID: MGI:3686863
• Synonyms: Lsc^-
• Gene: Arhgef1 Location: Chr7:24602337-24626019 bp, + strand Genetic Position: Chr7, 13.52 cM
• Alliance: Arhgef1^tm1.1Rmt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:113295
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Approximately 4.9 of sequence including the putative regulatory region and first exon was deleted via cre-mediated recombination. Transcript and protein were demonstrated to be absent by Northern and Western blot analyses, respectively. (J:113295)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Arhgef1 Mutation: 73 strains or lines available

References

• Original: J:113295 Rubtsov A, et al., Lsc regulates marginal-zone B cell migration and adhesion and is required for the IgM T-dependent antibody response. Immunity. 2005 Nov;23(5):527-38
• All: 7 reference(s)