Pycard^tm1Flv
Targeted Allele Detail

Summary

• Symbol: Pycard^tm1Flv
• Name: PYD and CARD domain containing; targeted mutation 1, Richard A Flavell
• MGI ID: MGI:3686870
• Synonyms: Asc^-, Pycard^-
• Gene: Pycard Location: Chr7:127590545-127593039 bp, - strand Genetic Position: Chr7, 69.88 cM, cytoband F4
• Alliance: Pycard^tm1Flv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:113333
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2, 3 and part of exon 1, including the ATG, were replaced with an IRES-LacZ-MC1-neo cassette. RT-PCR confirmed absence of transcript in mutant splenocytes. (J:113333)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pycard Mutation: 15 strains or lines available

References

• Original: J:113333 Sutterwala FS, et al., Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1. Immunity. 2006 Mar;24(3):317-27
• All: 92 reference(s)