Bank1^tm1Kuro
Targeted Allele Detail

Summary

• Symbol: Bank1^tm1Kuro
• Name: B cell scaffold protein with ankyrin repeats 1; targeted mutation 1, Tomohiro Kurosaki
• MGI ID: MGI:3686872
• Gene: Bank1 Location: Chr3:135759124-136031827 bp, - strand Genetic Position: Chr3, 63.04 cM
• Alliance: Bank1^tm1Kuro page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:113321
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Most of exon 2 was replaced with a neomycin resistance gene in reverse orientation. Absence of protein was confirmed by Western blot of mutant spleen. (J:113321)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bank1 Mutation: 58 strains or lines available

References

• Original: J:113321 Aiba Y, et al., BANK negatively regulates Akt activation and subsequent B cell responses. Immunity. 2006 Mar;24(3):259-68
• All: 3 reference(s)