Tnfrsf1a^tm2Gkl
Targeted Allele Detail

Summary

• Symbol: Tnfrsf1a^tm2Gkl
• Name: tumor necrosis factor receptor superfamily, member 1a; targeted mutation 2, George Kollias
• MGI ID: MGI:3686874
• Synonyms: p55TnfR^cneo, TnfRI^flxneo
• Gene: Tnfrsf1a Location: Chr6:125326686-125339446 bp, + strand Genetic Position: Chr6, 59.32 cM
• Alliance: Tnfrsf1a^tm2Gkl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:113314
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A floxed neo was inserted into intron 5 of the locus to create this conditional gain-of-function allele. The presence of the neo prevents expression of the gene. (J:113314)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tnfrsf1a Mutation: 52 strains or lines available

References

• Original: J:113314 Victoratos P, et al., FDC-specific functions of p55TNFR and IKK2 in the development of FDC networks and of antibody responses. Immunity. 2006 Jan;24(1):65-77
• All: 7 reference(s)