Mapk1^tm1Hed
Targeted Allele Detail

Summary

• Symbol: Mapk1^tm1Hed
• Name: mitogen-activated protein kinase 1; targeted mutation 1, Stephen M Hedrick
• MGI ID: MGI:3686887
• Synonyms: Erk2^fn
• Gene: Mapk1 Location: Chr16:16801246-16865317 bp, + strand Genetic Position: Chr16, 10.53 cM
• Alliance: Mapk1^tm1Hed page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:113280
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted into intron 3 and a floxed neo was inserted into intron 2. Western blot indicated that the neo did not affect translation of the protein. (J:113280)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)

	Allelic Composition	Genetic Background	Cell Line(s)
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cn1	Mapk1^tm1Hed/Mapk1^tm1Hed Mapk3^tm1Gpg/Mapk3^tm1Gpg Tg(Lck-cre)1Cwi/0	involves: 129/Sv * C57BL/6 * DBA/2
cn2	Mapk1^tm1Hed/Mapk1^tm1Hed Mapk3^tm1Gpg/Mapk3^tm1Gpg Tg(Cd4-cre)1Cwi/0	involves: 129/Sv * C57BL/6 * DBA/2
cn3	Mapk1^tm1Hed/Mapk1^tm1Hed Mapk3^tm1Gpg/Mapk3^tm1Gpg Tg(Cd4-cre)1Cwi/0 Tg(TcrAND)53Hed/0	involves: 129/Sv * C57BL/6 * DBA/2 * SJL
cn4	Mapk1^tm1Hed/Mapk1^tm1Hed Tg(Lck-cre)1Cwi/0	involves: C57BL/6 * DBA/2
cn5	Mapk1^tm1Hed/Mapk1^tm1Hed Tg(Cd4-cre)1Cwi/0	involves: C57BL/6 * DBA/2
cn6	Mapk1^tm1Hed/Mapk1^tm1Hed Tg(Lck-cre)1Cwi/0 Tg(TcrAND)53Hed/0	involves: C57BL/6 * DBA/2 * SJL
cx7	Mapk1^tm1Hed/Mapk1^tm1Hed Mapk3^tm1Gpg/Mapk3^tm1Gpg Tg(TcraTcrb)1100Mjb/0	involves: 129/Sv * C57BL/6
cx8	Mapk1^tm1Hed/Mapk1^tm1Hed Tg(TcraTcrb)1100Mjb/0	involves: C57BL/6
cx9	Mapk1^tm1Hed/Mapk1^tm1Hed Tg(TcrAND)53Hed/0	involves: C57BL/6 * DBA/2 * SJL

Phenotypes:

Affected Systems	cn1	cn2	cn3	cn4	cn5	cn6	cx7	cx8	cx9
show or hide all annotated terms
cellular	√			√
abnormal T cell proliferation	√
decreased T cell proliferation				√
endocrine/exocrine glands	√						√	√
small thymus	√
decreased thymocyte number	√						√	√
hematopoietic system	√	√	√	√	√	√	√	√	√
abnormal T cell proliferation	√
decreased T cell proliferation				√
small thymus	√
decreased thymocyte number	√						√	√
abnormal positive T cell selection		√	√		√	√			√
abnormal double-positive T cell morphology									√
decreased double-positive T cell number				√
increased double-positive T cell number	√				√
abnormal T cell subpopulation ratio			√	√		√
decreased CD4-positive, alpha-beta T cell number					√
decreased CD8-positive, alpha-beta T cell number					√
immune system	√	√	√	√	√	√	√	√	√
abnormal T cell proliferation	√
decreased T cell proliferation				√
small thymus	√
decreased thymocyte number	√						√	√
abnormal positive T cell selection		√	√		√	√			√
abnormal double-positive T cell morphology									√
decreased double-positive T cell number				√
increased double-positive T cell number	√				√
abnormal T cell subpopulation ratio			√	√		√
decreased CD4-positive, alpha-beta T cell number					√
decreased CD8-positive, alpha-beta T cell number					√

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mapk1 Mutation: 43 strains or lines available

References

• Original: J:113280 Fischer AM, et al., The role of erk1 and erk2 in multiple stages of T cell development. Immunity. 2005 Oct;23(4):431-43
• All: 5 reference(s)