Mapk1^tm2Hed
Targeted Allele Detail

Summary

• Symbol: Mapk1^tm2Hed
• Name: mitogen-activated protein kinase 1; targeted mutation 2, Stephen M Hedrick
• MGI ID: MGI:3686889
• Synonyms: Erk2^-
• Gene: Mapk1 Location: Chr16:16801246-16865317 bp, + strand Genetic Position: Chr16, 10.53 cM
• Alliance: Mapk1^tm2Hed page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:113280
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Disruption caused by insertion of vector
• Exons 3 and 4 were replaced with a neomycin resistance cassette. (J:113280)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mapk1 Mutation: 43 strains or lines available

References

• Original: J:113280 Fischer AM, et al., The role of erk1 and erk2 in multiple stages of T cell development. Immunity. 2005 Oct;23(4):431-43
• All: 2 reference(s)